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Bacteria
can produce ATP either aerobically or anaerobically. Anaerobic bacteria (in the
absence of oxygen) produce ATP by breaking down nutrients into simpler
metabolites, and using the energy released from the process to form ATP from
ADP. Aerobic bacteria produce ATP more
efficiently by further oxidizing (in the presence of oxygen) these resultant
metabolites to generate a promotive gradient along their inner membrane. The
enzymes that catalyze the oxidation are membrane bound, and they use the energy
released from the oxidation process to pump H+ from the cytosol to the other
side of the membrane. As the H+ ions pass back into the membrane through
specialized pumps, ATP is generated in an active site on these pumps.
Mitochondria produce ATP in exactly the same way. In fact, given the overwhelming
overlap in the genetic sequences and biochemical processes between mitochondria
and aerobic bacteria, it is now widely accepted that mitochondria evolved by
endosymbiosis of a proteobacterial ancestor within eukaryotic cells.
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